ea0029p677 | Diabetes | ICEECE2012
Villar R.
, Becerra A.
, Alameda C.
, Gonzalez P de Villar N.
, Canovas G.
, Cancer E.
, Rodriguez A.
, Perez-Lopez G.
, Menacho M.
Introduction: Mechanism underlying glucose-mediated development and progression of diabetic complication are incompletely understood. Atrial natriuretic peptide (ANP) is a hormone released by atrial myocytes in response to acute and chronic extracellular volume expansion. Moderate hyperglycaemia (>400 mg/dl) in diabetic rats is associated with an elevation in circulating ANP levels and in GFR (glomerular filtration rate), (1) and play a role in the development of microalbu...